Sr Scientist/Principal Scientist, Biology Pharmacology
Ascendis Pharma, Denmark

Join theBiology amp; Pharmacologyteam in a leading and fast-growing biotech company

Senior Scientist/Principal Scientist; Biology amp; Pharmacology

Ascendis Pharma is currently expanding its expertise within Biology amp; Pharmacology with specific scientific focus on endocrinology/growth plate biology.

You will join the Biology amp; Pharmacology Team in the SVP area of Non-Clinical Development and Bioanalysis. The team, which currently comprises three highly skilled and experienced biologists/pharmacologists, is responsible for defining and implementing integrated biology, non-clinical pharmacology, and translational biomarker strategies to support drug candidates from early innovative research to and through clinical development.

Main areas of responsibility:

• Be the scientific expert/go-to person within growth plate disorders, with specific focus on but not limited to the function of C-type natriuretic peptide

• Provide biology and pharmacology input to the TransCon CNP program (currently in phase II) and future clinical programs
• Initiate and co-ordinate non-clinical pharmacology studies to support one or more projects in collaboration with CROs
• Design, conduct and coordinate relevant in vivo pharmacology, pharmacokinetics, and proof-of-principle studies to support early research projects in collaboration with CROs
• Support identification of new therapy areas and setting up the nonclinical strategies to explore new targets
• Explore biology of new indications, targets and generate nonclinical ‘business cases’

• Write the pharmacology section of INDs/CTAs and contribute to other regulatory documents
• Publication of non-clinical efficacy/pharmacology and proof of principle data and reporting of scientific results in patents

You hold a PhD and/or post-doc training within a relevant biological, physiological or pharmacology science specialization with ideally 7 or more years’ experience focused on research and/or drug development. Relevant experience in the biotechnology or pharmaceutical industries and in working with CROs is considered an advantage.

You have

• A strong scientific and experimental background in endocrinology preferentially growth plate biology - and you enjoy integrating complex scientific ideas into hypothesis-driven strategies
• Experience in conducting animal studies, being the hands-on lead
• Demonstrated success and expertise in designing and implementing biology and pharmacology strategies/analyses
• Understanding of other relevant scientific disciplines including drug metabolism, drug transport, biopharmaceutics, and toxicology
• Experience in reporting scientific results via patents and publication of nonclinical efficacy, pharmacology, and proof of principle data
• Experience in drafting pharmacology section of INDs/CTAs and contributing to regulatory documents for submission is considered an advantage
• The ability to collaborate and communicate effectively with key stakeholders, present data and articulate seminal scientific questions and provide clear recommendations
• A detail- and quality-oriented mindset

You are proficient in English at a professional level, both written and spoken, and you master MS Office.

You are a highly motivated individual who enjoys being challenged and working in a collaborative scientific environment. You have a proactive and self-motivated mindset with a strong work ethic. You thrive in a dynamic working environment and are able to manage multiple objectives in parallel and adapt quickly to changing priorities. Strong interpersonal skills to enable effective communication, engagement and collaboration with colleagues in a multidisciplinary team environment is a must.

Ascendis Pharma offers you an exciting and challenging position in a young and dynamic team, driven by a strong scientific mindset in an entrepreneurial and international company with a short line of command. You will be involved in activities that are central to Ascendis Pharma’s strategy and work with highly skilled and experienced colleagues, together advancing Ascendis Pharma’s exciting product pipeline. As an expert within biology and pharmacology, you should expect to have an impact that corresponds to your level of expertise and knowledge in other words, your opinions will be greatly valued, and you will have a real impact on the company’s continued success.

Travelling: 10-20 days per year.

Place of work: Ascendis Pharma resides in a wonderful office facility in Tuborg Havn in Hellerup with a view to the harbour, the canals, and

Job Rewards and Benefits